纤维素纳米晶增强的壳聚糖-明胶-羟基磷灰石骨缺损修复支架

Cellulose Nanocrystal Reinforced Chitosan-Gelatin-Hydroxyapatite Scaffold for Bone Defect Repair

中文关键词:  纤维素纳米晶  骨缺损修复支架  壳聚糖  明胶  羟基磷灰石

Key Words:cellulose nanocrystal  bone defect repair scaffold  chitosan  gelatin  hydroxyapatite

中文摘要:

      纳米纤维素具有高模量、高强度、生物相容等优良特点，在生物医用领域展现出应用潜力。针对天然高分子骨缺损修复支架强度不足、降解过程机械强度下降等问题，采用纤维素纳米晶（CNC）予以改善。首先通过天然高分子凝胶化过程中的自组织，形成模拟天然骨中哈佛斯系统的壳聚糖-明胶-羟基磷灰石复合材料；进一步研究CNC对壳聚糖（CS）凝胶的增强作用；以CS-CNC复合凝胶为结构框架，通过界面融合可以形成组合凝胶；采用体外降解实验研究CS-CNC复合凝胶的降解。通过对天然生物质的仿生结构设计以及强度提升研究，探索CNC对提高支架综合性能的作用，发掘纳米纤维素在生物医用领域应用潜力。

Abstract:

      Nanocellulose has excellent characteristics such as high modulus， high strength， and biocompatibility， demonstrating potential applications in the biomedical field. This article aims to use cellulose nanocrystal （CNC） to address issues in the application of bone defect repair scaffolds， such as insufficient strength of natural polymer scaffolds and decreased mechanical strength during the degradation process. Firstly， the chitosan-gelatin-hydroxyapatite composite material simulating the Haversian system in natural bone was formed by self-organization. Then the strengthening effect of CNC on chitosan gel was studied. With CS-CNC composite gel as the structural framework， and chitosan-gelatin-hydroxyapatite composite as the biomimetic part， a combination hydrogel could be formed by interfacial fusion. Finally， the degradation of CS-CNC composite gel was studied in vitro. With the biomimetic structure design and the enhancement of natural polymer scaffold， this work aimed to explore the role of CNC in improving the performance of scaffolds， and explore the potential of nanocellulose in the application in biomedical field.