纳米纤维素基水凝胶在生物医学领域的研究进展

Research Progress of Nanocellulose-based Hydrogels for Biomedical Applications

中文关键词:  纳米纤维素  水凝胶  制备  生物医学应用

Key Words:nanocellulose  hydrogels  preparation  biomedical applications

中文摘要:

      纳米纤维素具有高比表面积（150~250 m²/g）、大长径比、低密度（1.6 g/cm³）和优越的机械性能（弹性模量~150 GPa，高拉伸强度~7.5 GPa）等特性，在生物医学等领域有着广泛的应用。本文主要对近几年纳米纤维素基水凝胶的研究进展进行了归纳总结。首先介绍了纳米纤维素的制备方法，包括机械法、酸水解法、TEMPO（2，2，6，6-四甲基哌啶-1-氧化物自由基）氧化法和生物法； 其次列举了制备纳米纤维素基水凝胶的常用交联方法，包括物理交联和化学交联；最后重点介绍了纳米纤维素基水凝胶在生物医学领域方面的应用，包括伤口敷料、组织工程和药物输送；此外，对纳米纤维素基水凝胶在生物医学领域的发展方向进行了展望。

Abstract:

      Nanocellulose has been widely used in biomedical and other fields because of its high specific surface area （150~250 m²/g）， large aspect ratio， low density （1.6 g/cm³） and excellent mechanical properties （elastic modulus ~150 GPa， high tensile strength ~7.5 GPa）. This paper mainly summarized the research progress of nanocellulose-based hydrogels in recent years. Firstly， the preparation methods of nanocellulose were introduced， including mechanical， acid hydrolysis， TEMPO oxidation and biological methods. Secondly， the common cross-linking methods of nanocellulose-based hydrogels， including physical crosslinking and chemical crosslinking， were listed. Finally， the applications of nanocellulose-based hydrogels in biomedical fields， including wound dressings， tissue engineering and drug delivery， were introduced. In addition， the development direction of nanocellulose-based hydrogels in biomedical field was prospected.