聚丙烯酰胺/聚氨酯耐压缩水凝胶的研究

Study on PAM/PU Compression-resistant Hydrogels

中文关键词:  聚丙烯酰胺  聚氨酯  水凝胶  柔韧性  耐压缩

Key Words:polyacrylamide  polyurethane  hydrogel  flexibility  compression-resistant

中文摘要:

      本研究介绍了聚丙烯酰胺（PAM）/聚氨酯（PU）耐压缩水凝胶的制备工艺。对水性PU和丙烯酰胺（AM）添加量的影响进行了系统研究，探究了不同PAM/PU水凝胶的耐压缩和抗溶胀性能，并探讨了其在关节软骨替代品中的应用潜力。结果表明，制备的PAM/PU水凝胶具有优异的耐压缩性能、回弹性及韧性。当AM水溶液质量分数为35%、PU（以固含量30%的PU乳液体积计）添加量为4 mL时，制备的AM65PU4 gel的耐压缩性能最优异，最大压缩率可达69%，压缩强度为2.1 MPa。此外，PAM/PU水凝胶显示出良好的抗溶胀性能，AM65PU4 gel去离子水中的平衡溶胀率为15%，碱性条件下为212%，酸性条件下为9%，适合用作关节软骨替代品植入人体，并长期稳定地发挥作用。

Abstract:

      This study introduced the preparation process of polyacrylamide （PAM）/polyurethane （PU） compression-resistant hydrogels. Firstly， a systematic study was conducted on the effects of addition amounts of water-based PU and acrylamide （AM）. Furtherly， the preformance of compression and swelling resistance of different PAM/PU hydrogels were investigated， and the potential of its application in articular cartilage substitutes was discussed. The results indicated that the prepared PAM/PU hydrogels exhibited excellent compressive strength， resilience， and toughness. When the mass fraction of AM aqueous solution was 35%， and the amount of PU （calculated by the volume of PU emulsion， solid content of 30%） added was 4 mL， the prepared AM65PU4 gel showed the most excellent compression-resistant performance， with the maximum compression rate up to 69%， and the compression strength of 2.1 MPa. In addition， the hydrogel showed good swelling resistance. The equilibrium swelling rate of AM65PU4 gel in deionized water was 15%， in alkaline condition was 212%， and in acid condition was 9%， which was suitable for use as articular cartilage， and could function stably for a long period of time.